Brain endothelial LRP1 maintains blood–brain barrier integrity
نویسندگان
چکیده
منابع مشابه
Endothelial LRP1 transports amyloid-β(1-42) across the blood-brain barrier.
According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor-related protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to neurotoxic amyloid-β (Aβ) brain accumulation and drives Alzheimer's disease (AD) pathology. However, due to conflicting reports on the involvement of LRP1 in Aβ transport and the expression of LRP1 in brain endoth...
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Interleukin (IL)-25, a member of the IL-17 family of cytokines, is expressed in the brains of normal mice. However, the cellular source of IL-25 and its function in the brain remain to be elucidated. Here, we show that IL-25 plays an important role in preventing infiltration of the inflammatory cells into the central nervous system. Brain capillary endothelial cells (BCECs) express IL-25. Howev...
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ژورنال
عنوان ژورنال: Fluids and Barriers of the CNS
سال: 2021
ISSN: 2045-8118
DOI: 10.1186/s12987-021-00260-5